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A Rare Case of Variant Hemoglobin (Hb Yahata) Suspected Based on Inconsistent Plasma Glucose and HbA1c Levels.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2015; Vol. 54 (14), pp. 1771-5. Date of Electronic Publication: 2015 Jul 15. - Publication Year :
- 2015
-
Abstract
- A 52-year-old man presented for an evaluation of worsening glycemic control secondary to glucocorticoid administration. The glycated hemoglobin (HbA1c) level was 8%, and oral glucose tolerance testing revealed impaired tolerance, whereas the plasma glucose and glycoalbumin levels were normal. The results of high-performance liquid chromatography (HPLC) for HbA1c, isoelectrofocusing of the hemolysate and precise HPLC measurements of the HbA1c level supported the presence of an Hb variant, and DNA sequencing of the β-globin gene revealed Hb Yahata [β112 TGT (Cys)→TAT (Tyr)] (heterozygote). In this case, the discrepancy between the plasma glucose and HbA1c levels raised suspicion of this rare Hb variant.
- Subjects :
- Blood Glucose genetics
Glucocorticoids adverse effects
Glucose Tolerance Test
Glycated Hemoglobin genetics
Glycation End Products, Advanced
Hemoglobins, Abnormal genetics
Humans
Male
Middle Aged
Neuromyelitis Optica blood
Sequence Analysis, DNA
Serum Albumin
Glycated Serum Albumin
Blood Glucose metabolism
Chromatography, High Pressure Liquid
Glucocorticoids administration & dosage
Glycated Hemoglobin metabolism
Hemoglobins, Abnormal isolation & purification
Neuromyelitis Optica drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 54
- Issue :
- 14
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 26179534
- Full Text :
- https://doi.org/10.2169/internalmedicine.54.4017