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New naphthopyrones from marine-derived fungus Aspergillus niger 2HL-M-8 and their in vitro antiproliferative activity.
- Source :
-
Natural product research [Nat Prod Res] 2016; Vol. 30 (10), pp. 1116-22. Date of Electronic Publication: 2015 Jul 15. - Publication Year :
- 2016
-
Abstract
- A new cytotoxic dimeric naphthopyrone, aurasperone H (1), together with eight related known polyketides (2-9) was isolated from a marine-derived fungus Aspergillus niger 2HL-M-8. The structure of new compound 1 was elucidated on the basis of its spectroscopic data (1D, 2D NMR and CD). Compound 1 exhibited moderate inhibitory activity against the human lung adenocarcinoma A549 and the human leukaemia HL-60 cell lines. Compound 5 displayed significant in vitro antiproliferative activity against HL-60 cell line with an IC50 value of 0.8 μM.
- Subjects :
- Antineoplastic Agents isolation & purification
Cell Line, Tumor drug effects
HL-60 Cells drug effects
Humans
Magnetic Resonance Spectroscopy
Marine Biology
Molecular Structure
Naphthalenes isolation & purification
Polyketides chemistry
Polyketides isolation & purification
Pyrones isolation & purification
Antineoplastic Agents pharmacology
Aspergillus niger chemistry
Naphthalenes pharmacology
Pyrones pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 30
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 26179399
- Full Text :
- https://doi.org/10.1080/14786419.2015.1043553