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New naphthopyrones from marine-derived fungus Aspergillus niger 2HL-M-8 and their in vitro antiproliferative activity.

Authors :
Li DH
Han T
Guan LP
Bai J
Zhao N
Li ZL
Wu X
Hua HM
Source :
Natural product research [Nat Prod Res] 2016; Vol. 30 (10), pp. 1116-22. Date of Electronic Publication: 2015 Jul 15.
Publication Year :
2016

Abstract

A new cytotoxic dimeric naphthopyrone, aurasperone H (1), together with eight related known polyketides (2-9) was isolated from a marine-derived fungus Aspergillus niger 2HL-M-8. The structure of new compound 1 was elucidated on the basis of its spectroscopic data (1D, 2D NMR and CD). Compound 1 exhibited moderate inhibitory activity against the human lung adenocarcinoma A549 and the human leukaemia HL-60 cell lines. Compound 5 displayed significant in vitro antiproliferative activity against HL-60 cell line with an IC50 value of 0.8 μM.

Details

Language :
English
ISSN :
1478-6427
Volume :
30
Issue :
10
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
26179399
Full Text :
https://doi.org/10.1080/14786419.2015.1043553