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Poorly Differentiated and Undifferentiated Thyroid Carcinomas.
- Source :
-
Turk patoloji dergisi [Turk Patoloji Derg] 2015; Vol. 31 Suppl 1, pp. 48-59. - Publication Year :
- 2015
-
Abstract
- Thyroid cancer is the most common endocrine malignancy and its incidence goes on increasing worldwide. The majority of thyroid tumours comprise well-differentiated (papillary and follicular) thyroid carcinomas that usually carry an excellent prognosis, while a minority progress to poorly differentiated carcinoma (PDTC) and, ultimately, to the highly aggressive and lethal undifferentiated carcinoma (UTC). Recently, some major advances have been made on the histologic and imunohistochemical identification, as well as on the molecular characterization of PDTC and UTC. In this review we summarize the most recent immunohistochemical and molecular findings in PDTC and UTC, giving a particular emphasis to the diagnostic and prognostic meaning of the genetic alterations.
- Subjects :
- Biomarkers, Tumor analysis
Biomarkers, Tumor genetics
Biopsy
Carcinoma chemistry
Carcinoma classification
Carcinoma genetics
Carcinoma therapy
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Molecular Diagnostic Techniques
Predictive Value of Tests
Prognosis
Thyroid Neoplasms chemistry
Thyroid Neoplasms classification
Thyroid Neoplasms genetics
Thyroid Neoplasms therapy
Carcinoma pathology
Cell Differentiation
Thyroid Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1309-5730
- Volume :
- 31 Suppl 1
- Database :
- MEDLINE
- Journal :
- Turk patoloji dergisi
- Publication Type :
- Academic Journal
- Accession number :
- 26177317
- Full Text :
- https://doi.org/10.5146/tjpath.2015.01314