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Biomarkers of delayed graft function as a form of acute kidney injury in kidney transplantation.
- Source :
-
Scientific reports [Sci Rep] 2015 Jul 15; Vol. 5, pp. 11684. Date of Electronic Publication: 2015 Jul 15. - Publication Year :
- 2015
-
Abstract
- Renal transplantation ensures distinct advantages for patients with end-stage kidney disease. However, in some cases early complications can lead to allograft dysfunction and consequently graft loss. One of the most common early complications after kidney transplantation is delayed graft function (DGF). Unfortunately there is no effective treatment for DGF, however early diagnosis of DGF and therapeutic intervention (eg modification of immunosuppression) may improve outcome. Therefore, markers of acute kidney injury are required. Creatinine is a poor biomarker for kidney injury due principally to its inability to help diagnose early acute renal failure and complete inability to help differentiate among its various causes. Different urinary and serum proteins have been intensively investigated as possible biomarkers in this setting. There are promising candidate biomarkers with the ability to detect DGF. We focused on emerging biomarkers of DGF with NGAL is being the most studied followed by KIM-1, L-FABP, IL-18, and others. However, large randomized studies are needed to establish the value of new, promising biomarkers, in DGF diagnosis, prognosis and its cost-effectiveness.
- Subjects :
- Acute-Phase Proteins urine
Adipokines urine
Biomarkers blood
Biomarkers urine
Chitinase-3-Like Protein 1
Clusterin urine
Creatinine blood
Cystatin C urine
Delayed Graft Function
Fatty Acid-Binding Proteins blood
Hepatitis A Virus Cellular Receptor 1
Humans
Interleukin-18 urine
Lectins urine
Lipocalin-2
Lipocalins urine
Membrane Glycoproteins analysis
Membrane Glycoproteins urine
Proto-Oncogene Proteins urine
Receptors, Virus analysis
Transplantation, Homologous
Acute Kidney Injury therapy
Biomarkers analysis
Kidney Transplantation
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 26175216
- Full Text :
- https://doi.org/10.1038/srep11684