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Etiology and antimicrobial resistance patterns in early and late neonatal sepsis in a Neonatal Intensive Care Unit.
- Source :
-
Archivos argentinos de pediatria [Arch Argent Pediatr] 2015 Aug; Vol. 113 (4), pp. 317-23. - Publication Year :
- 2015
-
Abstract
- Introduction: Neonatal sepsis is one of the main causes of death among newborn infants. Empirical antimicrobial treatment is based on epidemiological information and antimicrobial susceptibility tests. The objective of this study was to describe etiologic agents and their antimicrobial susceptibility among newborn infants with early-onset neonatal sepsis (EONS) or late-onset neonatal sepsis (LONS) at a Neonatal Intensive Care Unit.<br />Methods: Cross-sectional study conducted at a tertiary referral hospital in Western Mexico. Determination of antimicrobial resistance of microorganisms isolated in blood or cerebrospinal fluid of patients with EONS or nosocomial LONS.<br />Results: Yeasts and bacteria were isolated from 235 cultures corresponding to 67 events of EONS and 166 events of LONS. Of all isolates, the most common bacteria were Enterobacteriaceae (51.5%), followed by Streptococcus spp. in EONS, and by Staphylococcus spp. in LONS. Of all nosocomial Enterobacteriaceae, 40% were extended spectrum beta-lactamase producing bacteria. Among Staphylococcus species, resistance to oxacillin was recorded in 65.5%. Among Enterobacteriaceae (n: 121), resistance to amikacin, piperacillin-tazobactam, and meropenem was below 3%. Non-fermenting bacteria did not show resistance to amikacin, ciprofloxacin or cefepime; however, the number of isolates was scarce.<br />Conclusions: The most commonly identified bacteria in EONS were Enterobacteriaceae (67.6%) and Streptococcus spp. (17.6%), and Enterobacteriaceae (44.9%) and Staphylococcus spp. (34.7%) in LONS. Forty percent ofnosocomial Enterobacteriaceae were extended spectrum beta-lactamase producing bacteria, and 65.5% of Staphylococcus spp. showed resistance to oxacillin.
- Subjects :
- Age Factors
Anti-Bacterial Agents pharmacology
Cross-Sectional Studies
Drug Resistance, Bacterial
Enterobacteriaceae drug effects
Humans
Infant, Newborn
Intensive Care Units, Neonatal
Microbial Sensitivity Tests
Staphylococcus drug effects
Streptococcus drug effects
Anti-Bacterial Agents therapeutic use
Enterobacteriaceae Infections drug therapy
Neonatal Sepsis drug therapy
Neonatal Sepsis etiology
Staphylococcal Infections drug therapy
Streptococcal Infections drug therapy
Subjects
Details
- Language :
- English; Spanish; Castilian
- ISSN :
- 1668-3501
- Volume :
- 113
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Archivos argentinos de pediatria
- Publication Type :
- Academic Journal
- Accession number :
- 26172006
- Full Text :
- https://doi.org/10.5546/aap.2015.eng.317