Anticancer effect and mechanism of a Se-modified porphyrin Au(III) complex.

Authors :: Yang FR
Li Y
Zhang XH
Wang M
Guo HR
Ruan WJ
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Sep 01; Vol. 25 (17), pp. 3592-6. Date of Electronic Publication: 2015 Jun 27.
Publication Year :: 2015
Abstract: Au, Se and porphyrin are widely used components in the design of anticancer drugs, but their combination has never been referred to. In this work, a Se-modified porphyrin Au(III) complex, [AuTPP-Se]Cl, was designed and synthesized as a potential anticancer agent. This compound exhibits remarkable antiproliferative activity on all the six tested cancer cells. Its potency on HepG2 is even ten times higher than that of CDDP. The synergistic action among Au, Se and porphyrin components was validated. Mechanism study showed that both the induction of mitochondria-dependent apoptosis and the arrest of cell cycle contribute to the anticancer activity of [AuTPP-Se]Cl.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)