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Probiotic Lactobacillus rhamnosus GG therapy and microbiological programming in infantile colic: a randomized, controlled trial.
- Source :
-
Pediatric research [Pediatr Res] 2015 Oct; Vol. 78 (4), pp. 470-5. Date of Electronic Publication: 2015 Jul 07. - Publication Year :
- 2015
-
Abstract
- Background: Probiotic Lactobacillus reuteri and reduced allergen load may lessen the daily crying of colic infants, but the role of Lactobacillus rhamnosus GG (LGG) has remained obscure.<br />Methods: Infants with colic (n = 30) were enrolled during the first 6 wk of life. All families received behavioral support and allergen avoidance diet: breastfeeding mothers followed cow's milk elimination diet and formula-fed infants received extensively hydrolyzed casein formula. The randomized, double-blind intervention employed of LGG 4.5 × 10(9) cfu/d or placebo for a 4-wk study period. Daily crying was recorded by diaries and parental interviews. Fecal calprotectin and gut microbiota composition by quantitative PCR were evaluated before and after the intervention.<br />Results: Daily crying time was comparable between the probiotic (173 min) and the placebo group (174 min; P = 0.99) at the end of the intervention according to the parental diary. However, parents reported a decrease of 68% (95% confidence interval (CI): 58-78) in daily crying in the probiotic and 49% (95% CI: 32-66) in the placebo group (P = 0.05).<br />Conclusion: LGG in infants treated in tandem with behavioral support and a cow's milk elimination diet did not provide additional treatment effect for diary-verified colic crying although parental report of crying suggested the probiotic intervention effective.
- Subjects :
- Behavior Therapy
Bottle Feeding
Breast Feeding
Caseins administration & dosage
Colic diagnosis
Colic microbiology
Colic psychology
Combined Modality Therapy
Crying
DNA, Bacterial genetics
Double-Blind Method
Female
Finland
Humans
Infant
Infant Behavior
Infant Formula
Infant, Newborn
Interviews as Topic
Lacticaseibacillus rhamnosus genetics
Male
Polymerase Chain Reaction
Time Factors
Treatment Outcome
Colic therapy
Gastrointestinal Microbiome
Gastrointestinal Tract microbiology
Lacticaseibacillus rhamnosus growth & development
Probiotics therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1530-0447
- Volume :
- 78
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Pediatric research
- Publication Type :
- Academic Journal
- Accession number :
- 26151493
- Full Text :
- https://doi.org/10.1038/pr.2015.127