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Role of Procalcitonin and Interleukin-6 in Predicting Cancer, and Its Progression Independent of Infection.
- Source :
-
PloS one [PLoS One] 2015 Jul 06; Vol. 10 (7), pp. e0130999. Date of Electronic Publication: 2015 Jul 06 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Procalcitonin (PCT) and Interleukin-6 (IL-6) have emerged as biomarkers for different inflammatory conditions. The purpose of the study was to evaluate the role of PCT and IL-6 as biomarkers of cancer and its progression in a large cohort of patients. This cross-sectional study included residual plasma samples collected from cancer patients, and control subjects without cancer. Levels of PCT and IL-6 were determined by Kryptor compact bioanalyzer. We identified 575 febrile cancer patients, 410 non-febrile cancer patients, and 79 non-cancer individuals. The median PCT level was lower in control subjects (0.029 ng/ml) compared to cancer patients with stage I-III disease (0.127 ng/ml) (p<0.0001) and stage IV disease (0.190 ng/ml) (p<0.0001). It was also higher in febrile cancer patients (0.310 ng/ml) compared to non-febrile cancer patients (0.1 ng/ml) (p<0.0001). Median IL-6 level was significantly lower in the control group (0 pg/ml) than in non-febrile cancer patients with stages I-III (7.376 pg/ml) or stage IV (9.635 pg/ml) (p<0.0001). Our results suggest a potential role for PCT and IL-6 in predicting cancer in non-febrile patients. In addition, PCT is useful in detecting progression of cancer and predicting bacteremia or sepsis in febrile cancer patients.
- Subjects :
- Adolescent
Adult
Aged
Aged, 80 and over
Calcitonin Gene-Related Peptide
Child
Child, Preschool
Cross-Sectional Studies
Disease Progression
Humans
Middle Aged
Neoplasms blood
Young Adult
Biomarkers, Tumor
Calcitonin physiology
Interleukin-6 physiology
Neoplasms pathology
Protein Precursors physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 10
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 26148092
- Full Text :
- https://doi.org/10.1371/journal.pone.0130999