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Functional and oncological outcomes of open nephron-sparing surgery for complex renal masses.
Functional and oncological outcomes of open nephron-sparing surgery for complex renal masses.
- Source :
-
Urologic oncology [Urol Oncol] 2015 Oct; Vol. 33 (10), pp. 427.e11-6. Date of Electronic Publication: 2015 Jul 03. - Publication Year :
- 2015
-
Abstract
- Objective: To present our long-term functional and oncological outcomes in open nephron-sparing surgery for complex renal masses.<br />Patients and Methods: We enrolled 584 patients who underwent open partial nephrectomy between January 1995 and May 2014 at our institution; 108 (18.4%) patients had hilar or completely intraparenchymal tumors or both. We compared change in renal function, perioperative complications, and survival outcomes between complex and noncomplex renal masses.<br />Results: Mean tumor diameter was 4.3 and 3.5cm in patients with hilar and completely intraparenchymal lesions, respectively. R.E.N.A.L. nephrometry scores were significantly higher in patients with complex tumors as compared with patients with exophytic tumors. There was no significant difference between mean estimated glomerular filtration rate at last follow-up compared with preoperative mean estimated glomerular filtration rate in any of the groups. The incidence of perioperative complications was similar across all patients groups. Estimated 10-year cancer-specific survival probabilities were 100% in patients with hilar and intraparenchymal tumors. The 10-year recurrence-free survival probabilities were 96% and 95% in patients with hilar and intraparenchymal tumors, respectively. The main limitations include retrospective design and the lack of kidney-specific functional scan.<br />Conclusion: Open nephron-sparing surgery should be considered for complex renal masses yielding excellent functional and oncological outcomes without higher incidence of complications.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell mortality
Female
Humans
Kaplan-Meier Estimate
Kidney Neoplasms mortality
Male
Middle Aged
Postoperative Complications epidemiology
Retrospective Studies
Treatment Outcome
Carcinoma, Renal Cell surgery
Kidney Neoplasms surgery
Nephrectomy methods
Nephrons surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1873-2496
- Volume :
- 33
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Urologic oncology
- Publication Type :
- Academic Journal
- Accession number :
- 26145460
- Full Text :
- https://doi.org/10.1016/j.urolonc.2015.04.016