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Ragged-red fibres detected in paraffin sections by a monoclonal antibody to inner mitochondrial membrane.
Ragged-red fibres detected in paraffin sections by a monoclonal antibody to inner mitochondrial membrane.
- Source :
-
Journal of neurology [J Neurol] 1989 Dec; Vol. 236 (8), pp. 482-3. - Publication Year :
- 1989
-
Abstract
- An immunohistochemical method is reported using the M-II68 monoclonal antibody, which detects mitochondrial accumulations ("ragged-red fibres") in routinely processed (formalin-fixed, paraffin-embedded) muscle tissue. Ten cases with electron-microscopically and histochemically proven mitochondrial myopathy featured 4% to 24% ragged-red fibres. In a series of 50 muscle biopsies without mitochondrial myopathy, scattered ragged-red fibres (less than 0.1%) were present in a few normal and pathological muscles. The immunohistochemical method is specific for mitochondria, does not require frozen tissue and permits rapid examination of large areas.
Details
- Language :
- English
- ISSN :
- 0340-5354
- Volume :
- 236
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 2614495
- Full Text :
- https://doi.org/10.1007/BF00328512