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[Two Cases of Primary Intracranial Solitary Fibrous Tumor:Genetic Examination of NAB2-STAT6 Fusion and Its Association with Hemangiopericytoma].

Authors :
Kikuchi A
Fujita T
Takahashi Y
Yokosako S
Yoshimura C
Akagawa H
Fujibayashi M
Kubo O
Onda H
Kasuya H
Source :
No shinkei geka. Neurological surgery [No Shinkei Geka] 2015 Jul; Vol. 43 (7), pp. 641-8.
Publication Year :
2015

Abstract

Using whole exome and transcriptome sequencing, NAB2-STAT6 gene fusions have recently been identified in patients with solitary fibrous tumors (SFT). We report two cases of SFT in which NAB2-STAT6 fusions were identified. The patients were a 32-year-old man with a parasagittal tumor involving the superior sagittal sinus, and a 40-year-old man with a cerebellar convexity tumor partially involving the transverse sinus. Their tumors were gross totally resected and diagnosed to be SFT according to the following pathological findings:the tumors were composed of spindle cells with a patternless architecture, with prominent stromal collagen and staghorn vessels. An immunohistochemical study yielded positive results for CD34, CD99, and Bcl-2 and negative results for EMA, GFAP, and S100. The MIB-1 indexes were 13 and 7%, respectively. NAB2-STAT6 fusions were detected in both cases with a common fusion variant, NAB2ex6-STAT6ex16/17. We also identified NAB2-STAT6 fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17. These findings suggest that solitary fibrous tumor and hemangiopericytoma may be diagnosed based on the presence of NAB2-STAT6 fusion, and not classified separately because of the same genetic background.

Details

Language :
Japanese
ISSN :
0301-2603
Volume :
43
Issue :
7
Database :
MEDLINE
Journal :
No shinkei geka. Neurological surgery
Publication Type :
Academic Journal
Accession number :
26136329
Full Text :
https://doi.org/10.11477/mf.1436203090