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Interrelationships between Atopic Disorders in Children: A Meta-Analysis Based on ISAAC Questionnaires.
- Source :
-
PloS one [PLoS One] 2015 Jul 02; Vol. 10 (7), pp. e0131869. Date of Electronic Publication: 2015 Jul 02 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Purpose: To study the prevalence and interrelationship between asthma, allergic rhinitis and eczema using data obtained from ISAAC questionnaires.<br />Method: The Medline, Pubmed Publisher, EMBASE, Google Scholar and the Cochrane Controlled Clinical Trials Register databases were systematically reviewed to evaluate epidemiological data of children with atopic disorders. To study these interrelationships, a new approach was used. Risk ratios were calculated, describing the risk of having two different atopic disorders when the child is known with one disorder.<br />Results: Included were 31 studies, covering a large number of surveyed children (n=1,430,329) in 102 countries. The calculated worldwide prevalence for asthma, eczema and allergic rhinitis is 12.00% (95% CI: 11.99-12.00), 7.88% (95% CI: 7.88-7.89) and 12.66% (95% CI: 12.65-12.67), respectively. The observed prevalence [1.17% (95% CI: 1.17-1.17)] of having all three diseases is 9.8 times higher than could be expected by chance. For children with asthma the calculated risk ratio of having the other two disorders is 5.41 (95% CI: 4.76-6.16), for children with eczema 4.24 (95% CI: 3.75-4.79), and for children with allergic rhinitis 6.20 (95% CI: 5.30-7.27). No studied confounders had a significant influence on these risk ratios.<br />Conclusions: Only a minority of children suffers from all three atopic disorders, however this co-occurrence is significantly higher than could be expected by chance and supports a close relationship of these disorders in children. The data of this meta-analysis supports the hypothesis that there could be a fourth distinct group of children with all three disorders. Researchers and clinicians might need to consider these children as a separate group with distinct characteristics regarding severity, causes, treatment or prognosis.
- Subjects :
- Adolescent
Algorithms
Asthma complications
Child
Child, Preschool
Clinical Trials as Topic
Comorbidity
Databases, Factual
Eczema complications
Female
Humans
Infant
Infant, Newborn
Male
Models, Statistical
Prevalence
Probability
Registries
Rhinitis, Allergic complications
Surveys and Questionnaires
Asthma epidemiology
Eczema epidemiology
Rhinitis, Allergic epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 10
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 26135565
- Full Text :
- https://doi.org/10.1371/journal.pone.0131869