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Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
- Source :
-
Mucosal immunology [Mucosal Immunol] 2016 Jan; Vol. 9 (1), pp. 275-86. Date of Electronic Publication: 2015 Jul 01. - Publication Year :
- 2016
-
Abstract
- Group 2 innate lymphoid cells (ILC2s) have an important role in acute allergic lung inflammation. Given their distribution and function, lung ILC2s are hypothesized to coordinate epithelial responses to the external environment; however, how barrier surveillance is linked to ILC2 activation remains unclear. Here, we demonstrate that alveolar type II cells are the main source of interleukin (IL)-33 and thymic stromal lymphopoietin (TSLP) generated in response to chitin or migratory helminths. IL-33 and TSLP synergistically induce an interferon regulatory factor 4 (IRF4)-IL-9 program in ILC2s, and autocrine IL-9 promotes rapid IL-5 and IL-13 production required for optimal epithelial responses in the conducting airways. Thus, ILC2s link alveolar function to regulation of airway flow, revealing a key interaction between resident lymphoid and structural cells that might underlie similar organizational hierarchies in other organs.
- Subjects :
- Animals
Bronchoalveolar Lavage Fluid chemistry
Chitin
Cytokines genetics
Cytokines immunology
Epithelial Cells parasitology
Gene Expression Regulation
Immunity, Innate
Interferon Regulatory Factors genetics
Interleukin-13 genetics
Interleukin-13 immunology
Interleukin-33 genetics
Interleukin-33 immunology
Interleukin-5 genetics
Interleukin-5 immunology
Interleukin-9 genetics
Lung immunology
Lung parasitology
Lymphocytes parasitology
Mice
Mice, Inbred C57BL
Mice, Knockout
Nippostrongylus immunology
Nippostrongylus parasitology
Pneumonia chemically induced
Pneumonia genetics
Pneumonia pathology
Primary Cell Culture
Respiratory Mucosa immunology
Respiratory Mucosa parasitology
Signal Transduction
Strongylida Infections genetics
Strongylida Infections parasitology
Strongylida Infections pathology
Thymic Stromal Lymphopoietin
Epithelial Cells immunology
Interferon Regulatory Factors immunology
Interleukin-9 immunology
Lymphocytes immunology
Pneumonia immunology
Strongylida Infections immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1935-3456
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Mucosal immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26129648
- Full Text :
- https://doi.org/10.1038/mi.2015.59