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CT-Guided Percutaneous Cryoablation in Renal Cell Carcinoma: Factors Affecting Local Tumor Control.
- Source :
-
Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2015 Aug; Vol. 26 (8), pp. 1147-53. Date of Electronic Publication: 2015 Jun 27. - Publication Year :
- 2015
-
Abstract
- Purpose: To retrospectively evaluate factors affecting local tumor control in cryoablation of renal cell carcinomas (RCCs).<br />Materials and Methods: This study examined 61 patients (43 men, 18 women) with a mean age of 69.1 years ± 10.8 (range 38-87 y) who underwent computed tomography (CT)-guided percutaneous cryoablation for a single RCC and were followed for 6 months or longer. Maximum tumor diameter was 0.8-4.8 cm (mean ± standard deviation, 2.4 ± 0.9 cm). Factors affecting local tumor control were evaluated. Deep tumor location was defined as the center side of the body perpendicular to the kidney midline.<br />Results: Median follow-up was 12.7 months. Residual unablated tumors and local tumor progression were observed after initial cryoablation in 4 patients each (13%, 8 of 61). All uncontrolled tumors were located in the deep side of the kidney (100%, 8 of 8), and were covered by an ice-ball margin of 5 mm or less. Deep tumor location (P = .005) and ice-ball margin (P = .002) were detected as significant factors affecting local tumor control on univariate analysis, and ice-ball margin remained significant in a stepwise logistic regression model (P = .006; odds ratio, 0.57; 95% confidence interval, 0.38-0.83). Complete tumor control rates were 42.9% (3 of 7), 92.6% (50 of 54), and 100% (20 of 20) with ice-ball margins of less than 3 mm, 3 mm or larger, and 6 mm or larger, respectively.<br />Conclusions: Deep tumor location and ice-ball margins less than 6 mm were associated with incomplete local control following CT-guided percutaneous cryoablation for RCC.<br /> (Copyright © 2015 SIR. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell diagnostic imaging
Disease-Free Survival
Humans
Incidence
Japan epidemiology
Kidney Neoplasms diagnostic imaging
Middle Aged
Neoplasm Recurrence, Local mortality
Retrospective Studies
Risk Factors
Survival Rate
Tomography, X-Ray Computed statistics & numerical data
Treatment Outcome
Carcinoma, Renal Cell mortality
Carcinoma, Renal Cell surgery
Kidney Neoplasms mortality
Kidney Neoplasms surgery
Neoplasm Recurrence, Local prevention & control
Surgery, Computer-Assisted mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1535-7732
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of vascular and interventional radiology : JVIR
- Publication Type :
- Academic Journal
- Accession number :
- 26123809
- Full Text :
- https://doi.org/10.1016/j.jvir.2015.04.031