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Does EBV alter the pathogenesis of malaria?
- Source :
-
Parasite immunology [Parasite Immunol] 2015 Sep; Vol. 37 (9), pp. 433-45. - Publication Year :
- 2015
-
Abstract
- Plasmodium falciparum infections have been implicated in immune deficiencies resulting in ineffective control of Epstein-Barr virus, thereby increasing the risk of endemic Burkitt lymphoma in children. However, the impact of Epstein-Barr virus infections on the development of immunity to P. falciparum has not been studied in depth. In this review, we examine novel findings from animal co-infection models and human immuno-epidemiologic studies to speculate on the impact of acute gammaherpesvirus co-infection on malarial disease severity. Children are often concurrently or sequentially infected with multiple pathogens, and this has implications for understanding the development of protective immunity as well as in the evaluation of vaccine efficacy.<br /> (© 2015 John Wiley & Sons Ltd.)
- Subjects :
- Acute Disease
Africa South of the Sahara epidemiology
Animals
Burkitt Lymphoma parasitology
Burkitt Lymphoma virology
Child
Cytokines immunology
Disease Models, Animal
Epstein-Barr Virus Infections epidemiology
Humans
Malaria, Falciparum epidemiology
T-Lymphocytes immunology
Coinfection immunology
Epstein-Barr Virus Infections immunology
Herpesvirus 4, Human physiology
Malaria, Falciparum immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-3024
- Volume :
- 37
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Parasite immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26121587
- Full Text :
- https://doi.org/10.1111/pim.12212