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Prediction of development and maintenance of high albuminuria during chronic renin-angiotensin suppression by plasma proteomics.
- Source :
-
International journal of cardiology [Int J Cardiol] 2015 Oct 01; Vol. 196, pp. 170-7. Date of Electronic Publication: 2015 May 29. - Publication Year :
- 2015
-
Abstract
- Background: High albuminuria is a strong predictor of development of cardiovascular events in hypertensive patients. The search for predictors identifying patients at risk of developing high albuminuria or presenting a more rapid progression in this parameter may represent an effective strategy for adequate intervention and better outcome.<br />Methods and Results: Initially we investigated 24 patients presenting with normoalbuminuria, de novo albuminuria and sustained albuminuria. Plasma proteomics disclosed an upregulation of ceruloplasmin (CP), haptoglobin (HP) and alpha 1-acid glycoprotein (ORM1) that in a second step were selected for validation using turbidimetry assay in a cohort of 105 subjects. The validation showed that HP and ORM1 proteins were increased in patients presenting with very high albuminuria and potential irreversible kidney damage. CP and HP correlated positively with albuminuria values in normoalbuminuric patients. Finally, the levels of ORM1 and CP were increased in patients who progressed in their levels of albuminuria.<br />Conclusions: Our findings show that these proteins may potentially be useful for predicting the development of high albuminuria and to monitor renal damage.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Aged
Aged, 80 and over
Albuminuria blood
Disease Progression
Female
Haptoglobins metabolism
Humans
Kidney injuries
Male
Middle Aged
Nephelometry and Turbidimetry
Up-Regulation
Albuminuria diagnosis
Biomarkers blood
Ceruloplasmin metabolism
Hypertension complications
Orosomucoid metabolism
Proteomics methods
Renin-Angiotensin System drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1874-1754
- Volume :
- 196
- Database :
- MEDLINE
- Journal :
- International journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 26119064
- Full Text :
- https://doi.org/10.1016/j.ijcard.2015.05.148