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Biomimetic synthesized chiral mesoporous silica: Structures and controlled release functions as drug carrier.

Authors :
Li J
Xu L
Yang B
Bao Z
Pan W
Li S
Source :
Materials science & engineering. C, Materials for biological applications [Mater Sci Eng C Mater Biol Appl] 2015 Oct; Vol. 55, pp. 367-72. Date of Electronic Publication: 2015 May 09.
Publication Year :
2015

Abstract

This work initially illustrated the formation mechanism of chiral mesoporous silica (CMS) in a brand new insight named biomimetic synthesis. Three kinds of biomimetic synthesized CMS (B-CMS, including B-CMS1, B-CMS2 and B-CMS3) were prepared using different pH or stirring rate condition, and their characteristics were tested with transmission electron microscope and small angle X-ray diffraction. The model drug indomethacin was loaded into B-CMS and drug loading content was measured using ultraviolet spectroscopy. The result suggested that pH condition influenced energetics of self-assembly process, mainly packing energetics of the surfactant, while stirring rate was the more dominant factor to determine particle length. In application, indomethacin loading content was measured to be 35.3%, 34.8% and 35.1% for indomethacin loaded B-CMS1, indomethacin loaded B-CMS2 and indomethacin loaded B-CMS3. After loading indomethacin into B-CMS carriers, surface area, pore volume and pore diameter of B-CMS carriers were reduced. B-CMS converted crystalline state of indomethacin to amorphous state, leading to the improved indomethacin dissolution. B-CMS1 controlled drug release without burst-release, while B-CMS2 and B-CMS3 released indomethacin faster than B-CMS1, demonstrating that the particle length, the ordered lever of multiple helixes, the curvature degree of helical channels and pore diameter greatly contributed to the release behavior of indomethacin loaded B-CMS.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1873-0191
Volume :
55
Database :
MEDLINE
Journal :
Materials science & engineering. C, Materials for biological applications
Publication Type :
Academic Journal
Accession number :
26117767
Full Text :
https://doi.org/10.1016/j.msec.2015.05.039