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A Halogen-Containing Stilbene Derivative from the Leaves of Cajanus cajan that Induces Osteogenic Differentiation of Human Mesenchymal Stem Cells.
- Source :
-
Molecules (Basel, Switzerland) [Molecules] 2015 Jun 11; Vol. 20 (6), pp. 10839-47. Date of Electronic Publication: 2015 Jun 11. - Publication Year :
- 2015
-
Abstract
- A new natural halogen-containing stilbene derivative was isolated from the leaves of Cajanus cajan (L.) Millsp. and identified as 3-O-(3-chloro-2-hydroxyl-propanyl)-longistylin A by comprehensive spectroscopic and chemical analysis, and named cajanstilbene H (1). It is the first halogen-containing stilbene derivative found from plants. In human mesenchymal stem cells (hMSC) from bone marrow, 1 did not promote cell proliferation, but distinctly enhanced osteogenic differentiation of hMSC in time- and dose-dependent manners. In six human cancer cell lines, 1 showed a moderate inhibitory effect on cell proliferation, with IC50 values of 21.42-25.85 μmol·L(-1).
- Subjects :
- Cajanus chemistry
Halogens administration & dosage
Halogens chemistry
Humans
Plant Extracts chemistry
Plant Leaves chemistry
Stilbenes administration & dosage
Stilbenes chemistry
Cell Differentiation drug effects
Mesenchymal Stem Cells drug effects
Osteogenesis drug effects
Plant Extracts administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1420-3049
- Volume :
- 20
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Molecules (Basel, Switzerland)
- Publication Type :
- Academic Journal
- Accession number :
- 26111172
- Full Text :
- https://doi.org/10.3390/molecules200610839