Back to Search
Start Over
Phenomenon of individual difference in human monocyte activation.
- Source :
-
Experimental and molecular pathology [Exp Mol Pathol] 2015 Aug; Vol. 99 (1), pp. 151-4. Date of Electronic Publication: 2015 Jun 21. - Publication Year :
- 2015
-
Abstract
- Macrophages play an important role in the pathogenesis of atherosclerosis, including the early pre-clinical stages of the disease development. We have explored the possibility that the disease onset could be associated with altered monocyte/macrophage response to activating pro- and anti-inflammatory stimuli. We evaluated the susceptibility of circulating monocytes from healthy individuals and patients with asymptomatic carotid atherosclerosis to M1 and M2 activation. The obtained data indicated the existence of a remarkable individual difference in susceptibility to activation among monocytes isolated from the blood of different subjects, regardless of the presence or absence of atherosclerosis. The identified differences in susceptibility to activation between monocytes may explain the individual peculiarities of the immune response in different subjects.<br /> (Copyright © 2015. Published by Elsevier Inc.)
- Subjects :
- CD4-Positive T-Lymphocytes cytology
CD4-Positive T-Lymphocytes immunology
Carotid Artery Diseases pathology
Carotid Intima-Media Thickness
Chemokines, CC genetics
Chemokines, CC metabolism
Cross-Sectional Studies
Disease Progression
Humans
Immunity, Innate immunology
Macrophages
Monocytes metabolism
Tumor Necrosis Factor-alpha genetics
Tumor Necrosis Factor-alpha metabolism
Carotid Artery Diseases immunology
Monocytes cytology
Monocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0945
- Volume :
- 99
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Experimental and molecular pathology
- Publication Type :
- Academic Journal
- Accession number :
- 26107006
- Full Text :
- https://doi.org/10.1016/j.yexmp.2015.06.011