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Clinical experience of uterine tumors resembling ovarian sex cord tumors: a clinicopathological analysis of 6 cases.
- Source :
-
International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2015 Apr 01; Vol. 8 (4), pp. 4158-64. Date of Electronic Publication: 2015 Apr 01 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Objective: To compare the clinicopathological features, diagnosis, treatment, and prognosis of two types of uterine sex cord-like tumors.<br />Methods: The clinicopathological features of four uterine tumors resembling ovarian sex cord tumors (UTROSCTs) and two endometrial stromal tumors with sex cord-like elements (ESTSCLEs) were analyzed retrospectively.<br />Results: All patients were premenopausal women. The most common clinical presentation was vaginal bleeding (four cases). Total hysterectomy with or without bilateral adnexectomy was the most common treatment pattern (five cases). A patient with UTROSCTs, presenting with recurrence 10 months after transvaginal submucous myomectomy, underwent a total hysterectomy (case 2). All tumors were polypoid or intramural masses, usually located in the uterine fundus or submucosa. The majority of UTROSCTs were positive for cytokeratin (4/4 cases), one was positive for Wilms tumor protein, and of two cases with smooth muscle actin immunoreactivity, two were positive for desmin. UTROSCTs were positive for two or more sex cord markers, whereas sex cord markers were less frequently detected in ESTSCLEs. CD10 was variably positive in two UTROSCT patients and strongly positive in all ESTSCLE patients. Three UTROSCTs and one ESTSCLE were positive for both estrogen and progesterone receptors. All patients with UTROSCTs were alive without evidence of recurrence. One patient with ESTSCLEs underwent postoperative chemotherapy after total vaginal hysterectomy but developed recurrence at the vaginal stump (case 5). The other patient with ESTSCLEs was lost to follow-up.<br />Conclusion: These UTROSCTs are polymorphic neoplasms with true sex cord differentiation and uncertain malignant potential, which possess a distinct biology from ESTSCLEs.
- Subjects :
- Adult
Biomarkers, Tumor analysis
Chemotherapy, Adjuvant
Endometrial Neoplasms chemistry
Endometrial Neoplasms surgery
Endometrial Stromal Tumors chemistry
Endometrial Stromal Tumors surgery
Female
Gynecologic Surgical Procedures
Humans
Immunohistochemistry
Middle Aged
Neoplasm Recurrence, Local
Ovarian Neoplasms chemistry
Ovarian Neoplasms surgery
Premenopause
Reoperation
Sex Cord-Gonadal Stromal Tumors chemistry
Sex Cord-Gonadal Stromal Tumors surgery
Time Factors
Treatment Outcome
Endometrial Neoplasms pathology
Endometrial Stromal Tumors pathology
Ovarian Neoplasms pathology
Sex Cord-Gonadal Stromal Tumors pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2625
- Volume :
- 8
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of clinical and experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 26097607