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Increased expression of metastasis-associated in colon cancer-1 in renal cell carcinoma is associated with poor prognosis.
- Source :
-
International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2015 Apr 01; Vol. 8 (4), pp. 3857-63. Date of Electronic Publication: 2015 Apr 01 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Metastasis-associated in colon cancer-1 (MACC1) expression in tumor specimens is an independent prognostic indicator of metastasis, which has recently gained considerable attention in cancer research, due to its overexpression in several types of carcinoma. However, MACC1 expression patterns and its possible role in renal cell carcinoma remain unknown. This study aimed to investigate MACC1 expression in renal cell carcinoma via immunohistochemical analysis and determine the relationship between MACC1 expression and cancer prognosis. Positive MACC1 expression was found to significantly correlate with distant metastasis and TNM stage (P < 0.05). A Kaplan-Meier survival analysis revealed that patients with higher MACC1 expression had a significantly lower disease-free rate (P < 0.05). These results indicate that MACC1 expression is significantly associated with prognosis in patients with renal cell carcinoma. To the best of our knowledge, this is the first study on the significance of MACC1 as a prognostic marker in renal cell carcinoma. MACC1 expression may be a useful target for the development of new therapeutic approaches, including molecular targeted therapeutic agents, for renal cell carcinoma.
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Renal Cell pathology
Disease-Free Survival
Female
Humans
Kidney Neoplasms mortality
Kidney Neoplasms pathology
Male
Middle Aged
Neoplasm Metastasis pathology
Prognosis
Survival Rate
Trans-Activators
Up-Regulation
Carcinoma, Renal Cell metabolism
Kidney Neoplasms metabolism
Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2625
- Volume :
- 8
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- International journal of clinical and experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 26097569