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NKp30 isoforms in patients with chronic hepatitis C virus infection.
- Source :
-
Immunology [Immunology] 2015 Oct; Vol. 146 (2), pp. 234-42. Date of Electronic Publication: 2015 Jul 08. - Publication Year :
- 2015
-
Abstract
- Natural killer (NK) cells play an important role in virus infection, their action being regulated by several activating and inhibitory receptors. The NKp30 activating receptor and its isoforms have recently emerged as important determinants of efficient NK cell responses. We determined the relative proportions of NKp30 isoforms in patients with chronic hepatitis C virus (HCV) infection and healthy donors (HD). NK cell function (degranulation and cytokine production) and correlations with clinical parameters were assessed following unsupervised hierarchical clustering of patients according to isoform expression. NKp30 receptor expression on NK cells and all isoforms were reduced in HCV-infected patients. Patients were clustered into two groups: the HCV-1 group had similar isoform expression to the HD group, whereas the HCV-2 group had lower expression. The latter showed a better functional activity, and a higher proportion of the activating a isoform and of the NKp30 isoform a/c ratio compared with the HCV-1 cluster. There was a positive correlation between the activating a isoform and liver stiffness and an inverse relationship between the immunosuppressive c isoform and the fibrosis 4 score, suggesting a potentially important role of NKp30 isoforms in influencing liver damage and ensuing fibrosis.<br /> (© 2015 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Case-Control Studies
Cell Degranulation
Cell Line
Cluster Analysis
Coculture Techniques
Cytokines immunology
Cytokines metabolism
Disease Progression
Female
Genotype
Hepacivirus genetics
Hepacivirus pathogenicity
Hepatitis C, Chronic complications
Hepatitis C, Chronic diagnosis
Hepatitis C, Chronic genetics
Hepatitis C, Chronic metabolism
Host-Pathogen Interactions
Humans
Killer Cells, Natural metabolism
Killer Cells, Natural virology
Liver Cirrhosis immunology
Liver Cirrhosis pathology
Male
Middle Aged
Natural Cytotoxicity Triggering Receptor 3 genetics
Natural Cytotoxicity Triggering Receptor 3 metabolism
Phenotype
Prognosis
Protein Isoforms
Signal Transduction
Transfection
Hepacivirus immunology
Hepatitis C, Chronic immunology
Killer Cells, Natural immunology
Natural Cytotoxicity Triggering Receptor 3 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2567
- Volume :
- 146
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26094914
- Full Text :
- https://doi.org/10.1111/imm.12495