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High mobility group A1 expression shows negative correlation with recurrence time in patients with glioblastoma multiforme.
- Source :
-
Pathology, research and practice [Pathol Res Pract] 2015 Aug; Vol. 211 (8), pp. 596-600. Date of Electronic Publication: 2015 May 28. - Publication Year :
- 2015
-
Abstract
- The aim of this study was to explore the difference in high mobility group A1 (HMGA1) expression and isocitrate dehydrogenase (IDH) 1 R132H point mutation in initial and recurrent glioblastoma multiforme (GBM), and to further identify whether the expression of HMGA1 has a role in the malignant progression of GBM. Paired initial and recurrent GBM specimens from the same patient were evaluated using immunohistochemical analysis. The association between HMGA1 expression and progression-free survival time (PFST) was analyzed. Three patients were confirmed with IDH-1 R132H mutations in both initial and recurrent groups (3/25, 12%). There was a significant difference in HMGA1 expression between initial and recurrent GBM (P=0.002), and patients with tumors expressing HMGA1 at higher level had a significantly shorter PFST (7.3 months versus 11.1months; P=0.044). Our study indicates that recurrent GBM express HMGA1 at a higher level and that HMGA1 overexpressoin is associated with shorter PFST in patients with GBM. These findings suggest that HMGA1 potentially plays an important role in the treatment of GBM.<br /> (Copyright © 2015 Elsevier GmbH. All rights reserved.)
- Subjects :
- Adult
Brain Neoplasms genetics
Brain Neoplasms mortality
Brain Neoplasms pathology
Disease Progression
Disease-Free Survival
Female
Glioblastoma genetics
Glioblastoma mortality
HMGA Proteins genetics
Humans
Isocitrate Dehydrogenase genetics
Isocitrate Dehydrogenase metabolism
Male
Middle Aged
Mutation genetics
Neoplasm Recurrence, Local genetics
Brain Neoplasms metabolism
Glioblastoma metabolism
HMGA Proteins metabolism
Neoplasm Recurrence, Local pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1618-0631
- Volume :
- 211
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Pathology, research and practice
- Publication Type :
- Academic Journal
- Accession number :
- 26092597
- Full Text :
- https://doi.org/10.1016/j.prp.2015.05.004