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[Therapeutic activity of gemcitabine in intracranial tumors].
- Source :
-
Voprosy onkologii [Vopr Onkol] 2015; Vol. 61 (2), pp. 274-9. - Publication Year :
- 2015
-
Abstract
- Gemcitabine is known to exert a therapeutic effect on brain tumors despite the limited permeability of the blood-brain barrier (BBB). In our experimental research single intraperitoneal (i.p.) injection of gemcitabine 25 mg/kg provided increase in median survival of mice with intracranially transplanted Ehrlich carcinoma by 41-89% (p < 0.001). In this experimental model i.p. administration of gemcitabine (permeability of the BBB of less than 10%), carmustine (good permeability of the BBB), cyclophosphamide (poor permeability of the BBB) and cisplatin (doesn't penetrate through the BBB) increased median survival of mice by 88% (p < 0.001), 59% (p = 0.001), 35% (p = 0.005) and 18% (p = 0.302) respectively. Considering strong correlation between antitumor activity of the drugs (carmustine, cyclophosphamide and cisplatin) and their permeability of the BBB, efficacy of gemcitabine in intracranial tumors could be due to its wide range of therapeutic doses.
- Subjects :
- Animals
Antimetabolites, Antineoplastic administration & dosage
Brain Neoplasms etiology
Carmustine administration & dosage
Cisplatin administration & dosage
Cyclophosphamide administration & dosage
Deoxycytidine administration & dosage
Deoxycytidine pharmacology
Injections, Intraperitoneal
Male
Mice
Neoplasm Transplantation
Gemcitabine
Antimetabolites, Antineoplastic pharmacology
Antineoplastic Combined Chemotherapy Protocols pharmacology
Blood-Brain Barrier drug effects
Blood-Brain Barrier metabolism
Brain Neoplasms drug therapy
Carcinoma, Ehrlich Tumor drug therapy
Deoxycytidine analogs & derivatives
Subjects
Details
- Language :
- Russian
- ISSN :
- 0507-3758
- Volume :
- 61
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Voprosy onkologii
- Publication Type :
- Academic Journal
- Accession number :
- 26087611