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Requirement of Prefrontal and Midbrain Regions for Rapid Executive Control of Behavior in the Rat.
- Source :
-
Neuron [Neuron] 2015 Jun 17; Vol. 86 (6), pp. 1491-503. - Publication Year :
- 2015
-
Abstract
- To study rapid sensorimotor remapping, we developed a method to train rats in a behavior in which subjects are cued, on each trial, to apply a sensorimotor association to orient either toward a visual target ("Pro") or away from it, toward its reverse ("Anti"). Multiple behavioral asymmetries suggested that Anti behavior is cognitively demanding while Pro is easier to learn and perform. This is consistent with a prominent hypothesis in the primate literature that Anti requires prefrontal cortex (PFC), whereas Pro could be mediated by midbrain superior colliculus (SC). Pharmacological inactivation of rat medial PFC supported its expected role in Anti. Remarkably, bilateral SC inactivation substantially impaired Anti while leaving Pro essentially intact. Moreover, SC inactivation eliminated the performance cost of switching from Anti to Pro tasks. Our results establish a rodent model of single-trial sensorimotor remapping and suggest a critical role for SC in the cognitively demanding Anti task.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Analysis of Variance
Animals
Attention physiology
Brain Mapping
Executive Function drug effects
Functional Laterality drug effects
Functional Laterality physiology
GABA Agonists pharmacology
Inhibition, Psychological
Learning drug effects
Male
Muscimol pharmacology
Orientation drug effects
Prefrontal Cortex drug effects
Rats
Rats, Long-Evans
Reaction Time drug effects
Superior Colliculi drug effects
Executive Function physiology
Learning physiology
Orientation physiology
Prefrontal Cortex physiology
Superior Colliculi physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4199
- Volume :
- 86
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 26087166
- Full Text :
- https://doi.org/10.1016/j.neuron.2015.05.042