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Teotihuacanin, a Diterpene with an Unusual Spiro-10/6 System from Salvia amarissima with Potent Modulatory Activity of Multidrug Resistance in Cancer Cells.
- Source :
-
Organic letters [Org Lett] 2015 Jul 02; Vol. 17 (13), pp. 3280-2. Date of Electronic Publication: 2015 Jun 18. - Publication Year :
- 2015
-
Abstract
- Teotihuacanin (1), an unusual rearranged clerodane diterpene with a new carbon skeleton containing a spiro-10/6 bicyclic system, was isolated from the leaves and flowers of Salvia amarissima. Its structure was determined through spectroscopic analyses. Its absolute configuration was established by single-crystal X-ray diffraction. Compound 1 showed potent modulatory activity of multidrug resistance in vinblastine-resistant MCF-7 cancer cell line (reversal fold, RFMCF-7/Vin+ > 10703) at 25 μg/mL.
- Subjects :
- Crystallography, X-Ray
Diterpenes, Clerodane chemistry
Drug Resistance, Neoplasm drug effects
Drug Screening Assays, Antitumor
Female
HCT116 Cells
HeLa Cells
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Vinblastine pharmacology
Diterpenes, Clerodane isolation & purification
Diterpenes, Clerodane pharmacology
Salvia chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 17
- Issue :
- 13
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 26086893
- Full Text :
- https://doi.org/10.1021/acs.orglett.5b01320