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Continuous electrodermal activity as a potential novel neurophysiological biomarker of prognosis after cardiac arrest--A pilot study.
- Source :
-
Resuscitation [Resuscitation] 2015 Aug; Vol. 93, pp. 128-35. Date of Electronic Publication: 2015 Jun 15. - Publication Year :
- 2015
-
Abstract
- Aims: Neurological outcome prognosis remains challenging in patients undergoing therapeutic hypothermia (TH) after cardiac resuscitation. Technological advances allow for a novel wrist-worn device to continuously record electrodermal activity (EDA), a measure of pure sympathetic activity.<br />Methods: A prospective cohort study was performed to determine the yield of continuous EDA in patients treated with TH for coma after cardiac arrest during hypothermia and normothermia. Association between EDA parameters (event-related and nonspecific electrodermal responses (ER-EDR, NS-EDR)) and outcome measures (cerebral performance category [CPC]) (Full Outline in UnResponsivenss (FOUR) score) were assessed.<br />Results: Eighteen patients were enrolled. Total number of EDR (66.4 vs 12.0/24h, p = 0.02), ER-EDR (39.5 vs 11.2/24h, p = 0.009), median amplitude change of all EDR (0.08 vs 0.03 μSI, p = 0.03) and ER-EDR (0.14 vs 0.05 μSI, p = 0.025) were higher in patients with favorable (CPC 1-2) versus poor outcome (CPC 3-5) during hypothermia. Greater differences in EDA parameters were observed during hypothermia than normothermia. The FOUR score was correlated to the number of all EDR and median amplitudes.<br />Conclusions: Continuous EDA potentially opens a new avenue for autonomic function monitoring in neurocritically ill patients. It is feasible in the ICU setting, even during hypothermic states. As a measure of a complete neurophysiological circuit, it may be a novel neurophysiologic biomarker of outcome after cardiac resuscitation.<br /> (Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Aged
Cardiopulmonary Resuscitation adverse effects
Cardiopulmonary Resuscitation methods
Female
Humans
Male
Middle Aged
Neurologic Examination
Outcome and Process Assessment, Health Care
Pilot Projects
Prognosis
United States
Autonomic Nervous System Diseases diagnosis
Autonomic Nervous System Diseases etiology
Coma etiology
Coma therapy
Electrodiagnosis instrumentation
Electrodiagnosis methods
Galvanic Skin Response physiology
Heart Arrest complications
Heart Arrest therapy
Hypothermia, Induced adverse effects
Hypothermia, Induced methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-1570
- Volume :
- 93
- Database :
- MEDLINE
- Journal :
- Resuscitation
- Publication Type :
- Academic Journal
- Accession number :
- 26086420
- Full Text :
- https://doi.org/10.1016/j.resuscitation.2015.06.006