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Appropriateness of Twenty-four-Hour Antibiotic Prophylaxis After Spinal Surgery in Which a Drain Is Utilized: A Prospective Randomized Study.
- Source :
-
The Journal of bone and joint surgery. American volume [J Bone Joint Surg Am] 2015 Jun 17; Vol. 97 (12), pp. 979-86. - Publication Year :
- 2015
-
Abstract
- Background: Wound drains that are left in place for a prolonged period of time have a higher rate of bacterial contamination. Following spinal surgery, a drain is often left in place for a longer period of time if it maintains a high output. Given the major consequences of an infection following spinal surgery and the lack of data with regard to the use of antibiotics and drains, we performed a study of patients with a drain following spinal surgery to compare infection rates between those who were treated with antibiotics for twenty-four hours and those who received antibiotics for the duration for which the drain was in place.<br />Methods: We performed a prospective randomized trial of 314 patients who underwent multilevel thoracolumbar spinal surgery followed by use of a postoperative drain. The patients were randomized into two groups, one of which received perioperative antibiotics for twenty-four hours (twenty-four-hour group) and the other of which received antibiotics for the duration that the drain was in place (drain-duration group). Data collected included demographic characteristics, medical comorbidities, type of spinal surgery, and surgical site infection.<br />Results: Twenty-one (12.4%) of the 170 patients in the twenty-four-hour group and nineteen (13.2%) of the 144 in the drain-duration group developed a surgical site infection (p = 0.48). There were no significant differences between the twenty-four-hour and drain-duration groups with respect to demographic characteristics (except for the American Society of Anesthesiologists [ASA] classification), operative time, type of surgery, drain output, or length of hospital stay.<br />Conclusions: Continuing perioperative administration of antibiotics for the entire duration that a drain is in place after spinal surgery did not decrease the rate of surgical site infections.<br /> (Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated.)
Details
- Language :
- English
- ISSN :
- 1535-1386
- Volume :
- 97
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- The Journal of bone and joint surgery. American volume
- Publication Type :
- Academic Journal
- Accession number :
- 26085531
- Full Text :
- https://doi.org/10.2106/JBJS.L.00782