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Conformational characteristics of 4-acetylcytidine found in tRNA.
- Source :
-
Nucleic acids symposium series [Nucleic Acids Symp Ser] 1989 (21), pp. 61-2. - Publication Year :
- 1989
-
Abstract
- The conformational characteristics of a modified nucleoside 4-acetylcytidine (ac4C) was analyzed by proton nuclear magnetic resonance spectroscopy. This nucleoside was found to take the C3'-endo form predominantly. The enthalpy difference between the C2'-endo form and the C3'-endo form of the ribose moiety of ac4C was determined and 4-acetylation was found to stabilize the C3'-endo form further by 0.83 kcal.mol-1. This conformational characteristics of ac4C is probably important for the correct codon recognition and the stability of the tertiary structure of tRNA molecule.
Details
- Language :
- English
- ISSN :
- 0261-3166
- Issue :
- 21
- Database :
- MEDLINE
- Journal :
- Nucleic acids symposium series
- Publication Type :
- Academic Journal
- Accession number :
- 2608479