Selective Vaporization of Superheated Nanodroplets for Rapid, Sensitive, Acoustic Biosensing.

Authors :: Chattaraj R
Mohan P
Besmer JD
Goodwin AP
Source :: Advanced healthcare materials [Adv Healthc Mater] 2015 Aug 26; Vol. 4 (12), pp. 1790-5. Date of Electronic Publication: 2015 Jun 17.
Publication Year :: 2015
Abstract: Superheated perfluorocarbon nano-droplets exhibit promise as sensitive acoustic biosensors. Aggregation of biotin-decorated lipid-shelled droplets by streptavidin greatly increases the yield of bubbles formed by ultrasound-induced vaporization. Streptavidin is sensed down to 1 × 10(-13) m, with differentiable signal appearing in as little as two minutes, using a scalable assay without washing, processing, or development steps.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Biomarkers analysis
Biotin metabolism
Humans
Streptavidin metabolism
Ultrasonics
Volatilization
Biosensing Techniques methods
Fluorocarbons chemistry
Nanostructures chemistry

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