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Virus Genotype Distribution and Virus Burden in Children and Adults Hospitalized for Norovirus Gastroenteritis, 2012-2014, Hong Kong.
- Source :
-
Scientific reports [Sci Rep] 2015 Jun 17; Vol. 5, pp. 11507. Date of Electronic Publication: 2015 Jun 17. - Publication Year :
- 2015
-
Abstract
- We conducted a 2-year hospital-based study on norovirus gastroenteritis among children and adults between August 2012 and September 2014. A total of 1,146 norovirus cases were identified. Young children (aged ≤ 5 years) accounted for a majority (53.3%) of cases. Hospitalization incidence exhibited a U-shaped pattern with the highest rate in young children (1,475 per 100,000 person-years), followed by the elderly aged > 84 years (581 per 100,000 person-years). A subset (n = 395, 34.5%) of cases were selected for norovirus genotyping and noroviral load measurement. Non-GII.4 infections were more commonly observed in young children than in older adults (aged > 65 years) (20.5% versus 9.2%; p < 0.05). In young children, the median noroviral load of GII.4 and non-GII.4 cases was indistinguishably high (cycle threshold value, median [interquartile range]: 16.6 [15.2-19.3] versus 16.6 [14.9-21.6]; p = 0.45). Two age-specific non-GII.4 genotypes (GII.3 and GII.6) were identified among young children. These findings may have implications in norovirus vaccination strategy.
- Subjects :
- Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Caliciviridae Infections history
Child
Child, Preschool
Feces virology
Female
Gastroenteritis history
History, 21st Century
Hong Kong epidemiology
Humans
Infant
Infant, Newborn
Male
Middle Aged
RNA, Viral genetics
Young Adult
Caliciviridae Infections epidemiology
Caliciviridae Infections virology
Gastroenteritis epidemiology
Gastroenteritis virology
Genotype
Hospitalization
Norovirus genetics
Viral Load
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 26082165
- Full Text :
- https://doi.org/10.1038/srep11507