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Grading of Crohn's disease activity using CT, MRI, US and scintigraphy: a meta-analysis.
- Source :
-
European radiology [Eur Radiol] 2015 Nov; Vol. 25 (11), pp. 3295-313. Date of Electronic Publication: 2015 Jun 17. - Publication Year :
- 2015
-
Abstract
- Purpose: To assess the grading of Crohn's disease activity using CT, MRI, US and scintigraphy.<br />Materials and Methods: MEDLINE, EMBASE and Cochrane databases were searched (January 1983-March 2014) for studies evaluating CT, MRI, US and scintigraphy in grading Crohn's disease activity compared to endoscopy, biopsies or intraoperative findings. Two independent reviewers assessed the data. Three-by-three tables (none, mild, frank disease) were constructed for all studies, and estimates of accurate, over- and under-grading were calculated/summarized by fixed or random effects models.<br />Results: Our search yielded 9356 articles, 19 of which were included. Per-patient data showed accurate grading values for CT, MRI, US and scintigraphy of 86% (95% CI: 75-93%), 84% (95% CI: 67-93%), 44% (95% CI: 28-61%) and 40% (95% CI: 16-70%), respectively. In the per-patient analysis, CT and MRI showed similar accurate grading estimates (P = 0.8). Per-segment data showed accurate grading values for CT and scintigraphy of 87% (95% CI: 77-93%) and 86% (95% CI: 80-91%), respectively. MRI and US showed grading accuracies of 67-82% and 56-75%, respectively.<br />Conclusions: CT and MRI showed comparable high accurate grading estimates in the per-patient analysis. Results for US and scintigraphy were inconsistent, and limited data were available.<br />Key Points: • CT and MRI have comparable high accuracy in grading Crohn's disease. • Data on US and scintigraphy is inconsistent and limited. • MRI is preferable over CT as it lacks ionizing radiation exposure.
- Subjects :
- Adolescent
Adult
Aged
Crohn Disease diagnostic imaging
Female
Humans
Irritable Bowel Syndrome diagnostic imaging
Irritable Bowel Syndrome pathology
Magnetic Resonance Imaging
Male
Middle Aged
Positron-Emission Tomography
Reference Standards
Sensitivity and Specificity
Tomography, X-Ray Computed
Ultrasonography
Young Adult
Crohn Disease pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1084
- Volume :
- 25
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- European radiology
- Publication Type :
- Academic Journal
- Accession number :
- 26080794
- Full Text :
- https://doi.org/10.1007/s00330-015-3737-9