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Imatinib mesylate treatment in a dog with gastrointestinal stromal tumors with a c-kit mutation.
- Source :
-
The Journal of veterinary medical science [J Vet Med Sci] 2015 Nov; Vol. 77 (11), pp. 1535-9. Date of Electronic Publication: 2015 Jun 12. - Publication Year :
- 2015
-
Abstract
- A 13-year-old spayed mixed-breed dog was diagnosed with a gastrointestinal stromal tumor (GIST) after histopathological examination of an abdominal mass. Five months after surgical resection of the tumor, we detected the recurrence of GIST with multiple disseminated abdominal lesions. A sequence analysis of cDNA obtained from a biopsy of the recurrent tumors revealed a mutation within exon 9 of the c-kit gene (1523A>T, Asn(508)Ile), which has been shown to cause ligand-independent phosphorylation of the KIT protein in GISTs and canine mast cell tumors (MCTs). Upon detection of the recurrent tumors, we initiated treatment with imatinib mesylate (10 mg/kg, q 24 hr). After 2 months, the dog achieved complete remission. Our findings indicate that canine GIST, and possibly MCT, may be responsive to molecular-targeted therapy.
- Subjects :
- Animals
Antineoplastic Agents therapeutic use
DNA, Complementary
Dog Diseases metabolism
Dog Diseases surgery
Dogs
Female
Gastrointestinal Neoplasms drug therapy
Gastrointestinal Neoplasms metabolism
Gastrointestinal Stromal Tumors drug therapy
Gastrointestinal Stromal Tumors surgery
Gene Expression Regulation
Mutation
Proto-Oncogene Proteins c-kit genetics
Dog Diseases drug therapy
Gastrointestinal Neoplasms veterinary
Gastrointestinal Stromal Tumors veterinary
Imatinib Mesylate therapeutic use
Proto-Oncogene Proteins c-kit metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1347-7439
- Volume :
- 77
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- The Journal of veterinary medical science
- Publication Type :
- Academic Journal
- Accession number :
- 26074249
- Full Text :
- https://doi.org/10.1292/jvms.15-0096