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Observations of membrane fusion in a liposome dispersion: the missing fusion intermediate?
- Source :
-
F1000Research [F1000Res] 2015 Jan 08; Vol. 4, pp. 4. Date of Electronic Publication: 2015 Jan 08 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Early intermediate structures of liposome-liposome fusion events were captured by freeze-fracture electron microscopic (EM) technique. The images show the morphology of the fusion interface at several different stages of the fusion event. One of the intermediates was captured at a serendipitous stage of two vesicles' membranes (both leaflets) merging and their contents starting to intermix clearly showing the fusion interface with a previously unseen fusion rim. From the morphological information a hypothetical sequence of the fusion event and corresponding lipid structural arrangements are described.
Details
- Language :
- English
- ISSN :
- 2046-1402
- Volume :
- 4
- Database :
- MEDLINE
- Journal :
- F1000Research
- Publication Type :
- Academic Journal
- Accession number :
- 26069726.2
- Full Text :
- https://doi.org/10.12688/f1000research.6003.2