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From cardiac tissue engineering to heart-on-a-chip: beating challenges.

Authors :
Zhang YS
Aleman J
Arneri A
Bersini S
Piraino F
Shin SR
Dokmeci MR
Khademhosseini A
Source :
Biomedical materials (Bristol, England) [Biomed Mater] 2015 Jun 11; Vol. 10 (3), pp. 034006. Date of Electronic Publication: 2015 Jun 11.
Publication Year :
2015

Abstract

The heart is one of the most vital organs in the human body, which actively pumps the blood through the vascular network to supply nutrients to as well as to extract wastes from all other organs, maintaining the homeostasis of the biological system. Over the past few decades, tremendous efforts have been exerted in engineering functional cardiac tissues for heart regeneration via biomimetic approaches. More recently, progress has been made toward the transformation of knowledge obtained from cardiac tissue engineering to building physiologically relevant microfluidic human heart models (i.e. heart-on-chips) for applications in drug discovery. The advancement in stem cell technologies further provides the opportunity to create personalized in vitro models from cells derived from patients. Here, starting from heart biology, we review recent advances in engineering cardiac tissues and heart-on-a-chip platforms for their use in heart regeneration and cardiotoxic/cardiotherapeutic drug screening, and then briefly conclude with characterization techniques and personalization potential of the cardiac models.

Details

Language :
English
ISSN :
1748-605X
Volume :
10
Issue :
3
Database :
MEDLINE
Journal :
Biomedical materials (Bristol, England)
Publication Type :
Academic Journal
Accession number :
26065674
Full Text :
https://doi.org/10.1088/1748-6041/10/3/034006