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Pentamethylquercetin (PMQ) reduces thrombus formation by inhibiting platelet function.

Authors :
Liang ML
Da XW
He AD
Yao GQ
Xie W
Liu G
Xiang JZ
Ming ZY
Source :
Scientific reports [Sci Rep] 2015 Jun 10; Vol. 5, pp. 11142. Date of Electronic Publication: 2015 Jun 10.
Publication Year :
2015

Abstract

Flavonoids exert both anti-oxidant and anti-platelet activities in vitro and in vivo. Pentamethylquercetin (PMQ), a polymethoxylated flavone derivative, has been screened for anti-carcinogenic and cardioprotective effects. However, it is unclear whether PMQ has anti-thrombotic effects. In the present study, PMQ (20 mg/kg) significantly inhibited thrombus formation in the collagen- epinephrine- induced acute pulmonary thrombosis mouse model and the ferric chloride-induced carotid injury model. To explore the mechanism, we evaluated the effects of PMQ on platelet function. We found that PMQ inhibited platelet aggregation and granule secretion induced by low dose agonists, including ADP, collagen, thrombin and U46619. Biochemical analysis revealed that PMQ inhibited collagen-, thrombin- and U46619-induced activation of Syk, PLCγ2, Akt, GSK3β and Erk1/2. Therefore, we provide the first report to show that PMQ possesses anti-thrombotic activity in vivo and inhibited platelet function in vitro, suggesting that PMQ may represent a potential therapeutic candidate for the prevention or treatment of thrombotic disorders.

Details

Language :
English
ISSN :
2045-2322
Volume :
5
Database :
MEDLINE
Journal :
Scientific reports
Publication Type :
Academic Journal
Accession number :
26059557
Full Text :
https://doi.org/10.1038/srep11142