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Novel psoriasis therapies and patient outcomes, part 2: biologic treatments.

Authors :
Feely MA
Smith BL
Weinberg JM
Source :
Cutis [Cutis] 2015 May; Vol. 95 (5), pp. 282-90.
Publication Year :
2015

Abstract

Biologic treatments have revolutionized the management of psoriasis and psoriatic arthritis (PsA). Anti-tumor necrosis factor (TNF) α monoclonal antibodies presently are approved by the US Food and Drug Administration (FDA) for treatment of these conditions. In this article, new therapies that target this pathway and other steps in the pathogenesis of psoriasis and PsA are discussed, including IL-12/IL-23, IL-17, T-cell activation in antigen-presenting cells, regulatory T cells, toll-like receptors, and granulocyte-macrophage colony-stimulating factor. This article is the second in a 3-part series on treatments presently in the pipeline for the management of psoriasis and PsA including topical agents, biologic treatments, and systemic therapies in phase 2 through phase 4 clinical trials as well as agents that are recently FDA approved. Pivotal clinical trials, mechanisms of action, patient outcomes, and pertinent safety information will be discussed for each new therapy. As our knowledge of the underlying pathogenesis of psoriasis and PsA deepens, it enables the development of more targeted therapies in the management of these conditions.

Details

Language :
English
ISSN :
0011-4162
Volume :
95
Issue :
5
Database :
MEDLINE
Journal :
Cutis
Publication Type :
Academic Journal
Accession number :
26057506