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The Risk of Gestational Diabetes Mellitus Following Bereavement: A Cohort Study from Denmark and Sweden.
- Source :
-
Paediatric and perinatal epidemiology [Paediatr Perinat Epidemiol] 2015 Jul; Vol. 29 (4), pp. 271-80. Date of Electronic Publication: 2015 Jun 05. - Publication Year :
- 2015
-
Abstract
- Background: We investigated whether bereavement of a close family member - a source of severe psychological stress exposure - the year before pregnancy is associated with gestational diabetes mellitus (GDM).<br />Methods: We studied pregnant women with livebirths in Denmark during 1994-2008 and with births in Sweden during 1987-2006 (n = 2,569,446). We obtained data on death of women's parents, siblings, and older children, and on demographic and health- and pregnancy-related factors through linkage between nationwide registers.<br />Results: In multivariable models, death of a close relative the year before pregnancy was associated with a 14% increased odds of GDM [95% confidence intervals (CIs) 1.03, 1.26]. The odds ratios corresponding to the loss of a child, parent, and sibling were 1.51 (95% CI: 1.17, 1.95), 1.12 (95% CI: 1.00, 1.25), and 0.68 (95% CI: 0.40, 1.25), respectively. Deaths due to cardiovascular diseases or diabetes were more closely related to the risk of GDM than other types of deaths. We found no association between unnatural deaths and the risk of GDM.<br />Conclusions: Death of a close relative the year before pregnancy was associated with a modestly increased GDM risk. Our findings according to the relative's cause of death suggest that differences in screening for GDM among exposure groups and residual confounding by familial factors related to metabolic and cardiovascular diseases may have contributed to this association. If there is a causal stress effect on GDM in this predominantly Nordic population, it is most likely small.<br /> (© 2015 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Cohort Studies
Denmark epidemiology
Diabetes, Gestational epidemiology
Diabetes, Gestational psychology
Female
Gene-Environment Interaction
Humans
Hypertension epidemiology
Hypertension psychology
Life Change Events
Pregnancy
Registries
Risk Factors
Stress, Psychological epidemiology
Stress, Psychological psychology
Sweden epidemiology
Time Factors
Bereavement
Diabetes, Gestational etiology
Family psychology
Hypertension complications
Stress, Psychological complications
Subjects
Details
- Language :
- English
- ISSN :
- 1365-3016
- Volume :
- 29
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Paediatric and perinatal epidemiology
- Publication Type :
- Academic Journal
- Accession number :
- 26053686
- Full Text :
- https://doi.org/10.1111/ppe.12198