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Synthesis and Characterization of Hybrid Polymer/Lipid Expansile Nanoparticles: Imparting Surface Functionality for Targeting and Stability.
- Source :
-
Biomacromolecules [Biomacromolecules] 2015 Jul 13; Vol. 16 (7), pp. 1958-66. Date of Electronic Publication: 2015 Jun 19. - Publication Year :
- 2015
-
Abstract
- The size, drug loading, drug release kinetics, localization, biodistribution, and stability of a given polymeric nanoparticle (NP) system depend on the composition of the NP core as well as its surface properties. In this study, novel, pH-responsive, and lipid-coated NPs, which expand in size from a diameter of approximately 100 to 1000 nm in the presence of a mildly acidic pH environment, are synthesized and characterized. Specifically, a combined miniemulsion and free-radical polymerization method is used to prepare the NPs in the presence of PEGylated lipids. These PEGylated-lipid expansile NPs (PEG-L-eNPs) combine the swelling behavior of the polymeric core of expansile NPs with the improved colloidal stability and surface functionality of PEGylated liposomes. The surface functionality of PEG-L-eNPs allows for the incorporation of folic acid (FA) and folate receptor-targeting. The resulting hybrid polymer/lipid nanocarriers, FA-PEG-L-eNPs, exhibit greater in vitro uptake and potency when loaded with paclitaxel compared to nontargeted PEG-L-eNPs.
- Subjects :
- Antineoplastic Agents chemistry
Antineoplastic Agents pharmacokinetics
Cell Line, Tumor
Cell Survival drug effects
Chemistry, Pharmaceutical
Drug Delivery Systems
Folic Acid chemistry
HeLa Cells
Humans
Paclitaxel chemistry
Particle Size
Surface Properties
Antineoplastic Agents chemical synthesis
Folic Acid pharmacokinetics
Lipids chemistry
Nanoparticles chemistry
Paclitaxel pharmacokinetics
Polyethylene Glycols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1526-4602
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Biomacromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 26053219
- Full Text :
- https://doi.org/10.1021/acs.biomac.5b00336