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An ethnopharmacological approach to the preliminary screening of native Australian herbal medicines for anticancer activity.
- Source :
-
Journal of complementary & integrative medicine [J Complement Integr Med] 2015 Sep; Vol. 12 (3), pp. 245-9. - Publication Year :
- 2015
-
Abstract
- Background: Five plants used traditionally by Australian Aboriginals and two edible native Australian fruits have been investigated for anticancer activity. The aim was to identify native Australian herbal medicines which displayed anticancer activity, with cytotoxicity to cancer cells but sparing or even proliferating normal immunological cells, and subsequently provide potentially new anticancer drug leads.<br />Methods: Extracts and derived fractions were assayed for cell viability against a multiple myeloma cell line, RPMI-8226, in comparison to the peripheral blood mononuclear cells (PBMC) representing normal human immunological cells.<br />Results: None of the crude extracts exhibited the desirable differential activity; however, following further fractionation of the Eremophila duttonii F. Muell. (Myoporaceae) extract, one fraction (termed F01) exhibited a greater cytotoxicity to the cancer cell line than to the normal cells.<br />Conclusions: One fraction may potentially contain valuable compounds which may be useful for further investigation. This may focus on the identification of the bioavailable purified compounds present within these fractions or by detailed delineation of the related mechanisms of action.
- Subjects :
- Acacia chemistry
Alstonia chemistry
Australia
Cell Survival drug effects
Eremophila Plant chemistry
Fruit chemistry
Humans
Medicine, Traditional
Native Hawaiian or Other Pacific Islander
Antineoplastic Agents pharmacology
Cell Line, Tumor drug effects
Herbal Medicine
Leukocytes, Mononuclear drug effects
Multiple Myeloma drug therapy
Plant Extracts pharmacology
Plants, Medicinal chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1553-3840
- Volume :
- 12
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of complementary & integrative medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26053015
- Full Text :
- https://doi.org/10.1515/jcim-2014-0017