Back to Search
Start Over
X-ray structurally characterized sensors for ratiometric detection of Zn(2+) and Al(3+) in human breast cancer cells (MCF7): development of a binary logic gate as a molecular switch.
- Source :
-
Dalton transactions (Cambridge, England : 2003) [Dalton Trans] 2015 Jul 14; Vol. 44 (26), pp. 11797-804. Date of Electronic Publication: 2015 Jun 08. - Publication Year :
- 2015
-
Abstract
- A very simple molecule derived from salicylaldehyde and N-phenyl ethylenediamine (L1) functions as dual-mode ratiometric fluorescence "turn on" sensors for Zn(2+) and Al(3+) at two different wavelengths. The sensing is based on the combined effect of inhibition of excited-state intra-molecular proton transfer (ESIPT), CH=N isomerization and chelation-enhanced fluorescence (CHEF). Moreover, the [L1-Zn(2+)] system functions as a better Al(3+) sensor where Al(3+) ratiometrically displaces Zn(2+) from the [L1-Zn(2+)] complex. Emission wavelength dependent differentiation of Zn(2+) and Al(3+) using L1 allows us to develop a binary logic gate that functions as a molecular switch. L1 efficiently detects Zn(2+) and Al(3+) in human breast cancer cells (MCF7) while the [L1-Zn(2+)] complex specifically detects Al(3+) in the said cells.
- Subjects :
- Breast chemistry
Breast pathology
Breast Neoplasms pathology
Cations analysis
Chelating Agents chemistry
Crystallography, X-Ray
Female
Humans
MCF-7 Cells
Optical Imaging
Spectrometry, Fluorescence
Aldehydes chemistry
Aluminum analysis
Breast Neoplasms chemistry
Ethylenediamines chemistry
Fluorescent Dyes chemistry
Zinc analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1477-9234
- Volume :
- 44
- Issue :
- 26
- Database :
- MEDLINE
- Journal :
- Dalton transactions (Cambridge, England : 2003)
- Publication Type :
- Academic Journal
- Accession number :
- 26051452
- Full Text :
- https://doi.org/10.1039/c5dt01303h