Back to Search
Start Over
[The synthesis of ψ-(2-aryl-1,3-dioxolan-2-yl) alkyl derivatives of purines and their activity towards HIV reverse transcriptase].
- Source :
-
Bioorganicheskaia khimiia [Bioorg Khim] 2015 Jan-Feb; Vol. 41 (1), pp. 44-53. - Publication Year :
- 2015
-
Abstract
- Novel non-competitive inhibitors of HIV RT were synthesized by alkylation of 6-substituted purines with different 2-(chloroalkyl)-2-aryl-1,3-dioxolanes and related compounds. The structure-activity relationship within the synthesized compounds was studied.
- Subjects :
- HIV Reverse Transcriptase chemistry
Humans
Anti-HIV Agents chemical synthesis
Anti-HIV Agents chemistry
HIV Reverse Transcriptase antagonists & inhibitors
HIV-1 enzymology
Purines chemical synthesis
Purines chemistry
Reverse Transcriptase Inhibitors chemical synthesis
Reverse Transcriptase Inhibitors chemistry
Subjects
Details
- Language :
- Russian
- ISSN :
- 0132-3423
- Volume :
- 41
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bioorganicheskaia khimiia
- Publication Type :
- Academic Journal
- Accession number :
- 26050471
- Full Text :
- https://doi.org/10.1134/s1068162015010069