An efficient synthesis and in vitro antibacterial evaluation of ruthenium-quinolinol complexes.

Authors :: Malipeddi M
Lakhani C
Chhabra M
Paira P
Vidya R
Source :: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Aug 01; Vol. 25 (15), pp. 2892-6. Date of Electronic Publication: 2015 May 30.
Publication Year :: 2015
Abstract: A series of ruthenium-quinolinol complexes were synthesized using a simple and effective pathway and their in vitro antibacterial activity against various resistant gram-positive and gram-negative bacteria were evaluated. It was established that compound [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) & [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3e) were significantly active against Staphylococcus aureus, Escherichia coli, Bacillus subtilis &Salmonella sp. The structures of the new compounds were elucidated by the analysis of spectroscopic data. The stability of complex [(η6-pcymene)RuCl(κ2-O,N-5,7-dibromo-HyQ)]·Cl (3b) was measured by UV spectroscopy & time dependent NMR spectroscopy. Compound 3b also shows remarkable fluorescence.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)

Subjects :: Bacillus subtilis drug effects
Bacterial Infections drug therapy
Coordination Complexes chemical synthesis
Coordination Complexes chemistry
Coordination Complexes pharmacology
Escherichia coli drug effects
Humans
Hydroxyquinolines chemical synthesis
Microbial Sensitivity Tests
Salmonella drug effects
Staphylococcus aureus drug effects
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Hydroxyquinolines chemistry
Hydroxyquinolines pharmacology
Ruthenium chemistry
Ruthenium pharmacology

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