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Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS.
- Source :
-
PloS one [PLoS One] 2015 Jun 05; Vol. 10 (6), pp. e0122686. Date of Electronic Publication: 2015 Jun 05 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- Background: Multiple Sclerosis is more common in women than men and females have more relapses than men. In a large international cohort we have evaluated the effect of gender on disability accumulation and disease progression to determine if male MS patients have a worse clinical outcome than females.<br />Methods: Using the MSBase Registry, data from 15,826 MS patients from 25 countries was analysed. Changes in the severity of MS (EDSS) were compared between sexes using a repeated measures analysis in generalised linear mixed models. Kaplan-Meier analysis was used to test for sex difference in the time to reach EDSS milestones 3 and 6 and the secondary progressive MS.<br />Results: In relapse onset MS patients (n = 14,453), males progressed significantly faster in their EDSS than females (0.133 vs 0.112 per year, P<0.001,). Females had a reduced risk of secondary progressive MS (HR (95% CI) = 0.77 (0.67 to 0.90) P = 0.001). In primary progressive MS (n = 1,373), there was a significant increase in EDSS over time in males and females (P<0.001) but there was no significant sex effect on the annualized rate of EDSS change.<br />Conclusion: Among registrants of MSBase, male relapse-onset patients accumulate disability faster than female patients. In contrast, the rate of disability accumulation between male and female patients with primary progressive MS is similar.
- Subjects :
- Adult
Aged
Cohort Studies
Databases, Factual
Disability Evaluation
Disease Progression
Female
Humans
Immunologic Factors therapeutic use
Kaplan-Meier Estimate
Male
Middle Aged
Multiple Sclerosis drug therapy
Multiple Sclerosis mortality
Proportional Hazards Models
Recurrence
Registries
Severity of Illness Index
Sex Factors
Multiple Sclerosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 10
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 26046348
- Full Text :
- https://doi.org/10.1371/journal.pone.0122686