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Progesterone receptor status and clinical outcome in breast cancer patients with estrogen receptor-positive locoregional recurrence.
- Source :
-
Tumori [Tumori] 2015 Jul-Aug; Vol. 101 (4), pp. 398-403. Date of Electronic Publication: 2015 May 22. - Publication Year :
- 2015
-
Abstract
- Aims and Background: The aim of this retrospective multicenter study was to evaluate the impact of progesterone receptor (PgR) loss on locoregional recurrence in patients with estrogen receptor (ER)-positive primary breast cancer and ER-positive locoregional recurrence.<br />Patients and Methods: Eight Italian oncology centers collected data from consecutive patients with ER-positive breast cancer and a subsequent ER-positive locoregional recurrence.<br />Results: Data were available for 265 patients diagnosed with breast cancer between 1990 and 2009. Median metastasis-free survival was 111 months in patients with PgR-positive primary tumors and locoregional recurrence (PgRpos), 38 months in patients with PgR-negative primary tumors and locoregional recurrence (PgRneg), and 63 months in patients with PgR-positive primary tumors and PgR-negative locoregional recurrence (PgRloss). In multivariate analysis, PgR status was independently associated with metastasis-free survival, with a hazard ratio of 2.84 (95% CI 1.34-6.00) for PgRneg compared with PgRpos, and 2.93 (95% CI: 1.51-5.70) for PgRloss compared with PgRpos.<br />Conclusions: PgR absence was found to be a negative prognostic factor in breast cancer patients with ER-positive locoregional recurrence. Thus, PgR status could be a biological marker in ER-positive recurrent breast cancer.
- Subjects :
- Adult
Aged
Aged, 80 and over
Cell Proliferation
Disease-Free Survival
Female
Humans
Italy
Lymphatic Metastasis
Middle Aged
Neoplasm Grading
Neoplasm Staging
Odds Ratio
Predictive Value of Tests
Receptor, ErbB-2 analysis
Retrospective Studies
Time Factors
Biomarkers, Tumor analysis
Breast Neoplasms chemistry
Breast Neoplasms pathology
Neoplasm Recurrence, Local chemistry
Neoplasm Recurrence, Local pathology
Receptors, Estrogen analysis
Receptors, Progesterone analysis
Subjects
Details
- Language :
- English
- ISSN :
- 2038-2529
- Volume :
- 101
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Tumori
- Publication Type :
- Academic Journal
- Accession number :
- 26045108
- Full Text :
- https://doi.org/10.5301/tj.5000323