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Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes.
- Source :
-
Circulation research [Circ Res] 2015 Jun 05; Vol. 116 (12), pp. 1989-2004. - Publication Year :
- 2015
-
Abstract
- Sudden cardiac death is a common cause of death in patients with structural heart disease, genetic mutations, or acquired disorders affecting cardiac ion channels. A wide range of platforms exist to model and study disorders associated with sudden cardiac death. Human clinical studies are cumbersome and are thwarted by the extent of investigation that can be performed on human subjects. Animal models are limited by their degree of homology to human cardiac electrophysiology, including ion channel expression. Most commonly used cellular models are cellular transfection models, which are able to mimic the expression of a single-ion channel offering incomplete insight into changes of the action potential profile. Induced pluripotent stem cell-derived cardiomyocytes resemble, but are not identical, adult human cardiomyocytes and provide a new platform for studying arrhythmic disorders leading to sudden cardiac death. A variety of platforms exist to phenotype cellular models, including conventional and automated patch clamp, multielectrode array, and computational modeling. Induced pluripotent stem cell-derived cardiomyocytes have been used to study long QT syndrome, catecholaminergic polymorphic ventricular tachycardia, hypertrophic cardiomyopathy, and other hereditary cardiac disorders. Although induced pluripotent stem cell-derived cardiomyocytes are distinct from adult cardiomyocytes, they provide a robust platform to advance the science and clinical care of sudden cardiac death.<br /> (© 2015 American Heart Association, Inc.)
- Subjects :
- Animals
Cardiovascular Agents pharmacology
Cell Differentiation drug effects
Cells, Cultured
Clinical Trials as Topic methods
Computer Simulation
Disease Models, Animal
Drug Evaluation, Preclinical methods
Electrophysiology methods
Forecasting
Heart Diseases complications
Heart Diseases genetics
Heart Diseases pathology
Humans
Ion Channels physiology
Long QT Syndrome genetics
Long QT Syndrome pathology
Long QT Syndrome physiopathology
Models, Cardiovascular
Myocytes, Cardiac cytology
Myocytes, Cardiac drug effects
Organ Culture Techniques
Patch-Clamp Techniques methods
Tachycardia, Ventricular genetics
Tachycardia, Ventricular pathology
Tachycardia, Ventricular physiopathology
Death, Sudden, Cardiac etiology
Induced Pluripotent Stem Cells cytology
Myocytes, Cardiac physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4571
- Volume :
- 116
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Circulation research
- Publication Type :
- Academic Journal
- Accession number :
- 26044252
- Full Text :
- https://doi.org/10.1161/CIRCRESAHA.116.304494