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Physical exercise affects attentional orienting behavior through noradrenergic mechanisms.
- Source :
-
Behavioral neuroscience [Behav Neurosci] 2015 Jun; Vol. 129 (3), pp. 361-7. - Publication Year :
- 2015
-
Abstract
- Spontaneously hypertensive rats (SHRs), a commonly used animal model of attention-deficit/hyperactivity disorder, exhibit little habituation of the orienting response to repeated presentations of a nonreinforced visual stimulus. However, SHRs that have access to a running wheel for 5, 10, or 21 days exhibit robust habituation that is indistinguishable from normo-active rats. Two days of exercise, in comparison, is not sufficient to affect habituation. Here we tested the hypothesis that the effect of exercise on orienting behavior in SHRs is mediated by changes in noradrenergic function. In Experiment 1, we found that 5, 10, or 21 days of access to a running wheel, but not 2 days, significantly reduced levels of the norepinephrine transporter in medial prefrontal cortex. In Experiment 2, we tested for a causal relationship between changes in noradrenergic function and orienting behavior by blocking noradrenergic receptors during exercise. Rats that received propranolol (beta adrenergic/noradrenergic receptor blocker) during 10 days of exercise failed to exhibit an exercise-induced reduction in orienting behavior. The results inform a growing literature regarding the effects of exercise on behavior and the potential use of exercise as a treatment for mental disorders.<br /> ((c) 2015 APA, all rights reserved).)
- Subjects :
- Adrenergic beta-Antagonists pharmacology
Animals
Attention Deficit Disorder with Hyperactivity physiopathology
Blotting, Western
Disease Models, Animal
Female
Orientation drug effects
Prefrontal Cortex drug effects
Propranolol pharmacology
Rats, Inbred SHR
Time Factors
Norepinephrine metabolism
Orientation physiology
Physical Conditioning, Animal physiology
Prefrontal Cortex physiopathology
Running physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1939-0084
- Volume :
- 129
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Behavioral neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 26030434
- Full Text :
- https://doi.org/10.1037/bne0000054