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Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma.
- Source :
-
Anticancer research [Anticancer Res] 2015 Jun; Vol. 35 (6), pp. 3571-4. - Publication Year :
- 2015
-
Abstract
- Aim: Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types.<br />Patients and Methods: Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy.<br />Results: SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p<0.001). Results were also significant on multivariate analysis (risk ratio: 6.30; p=0.033). SRS dose did not associate with freedom from new cerebral metastases (75% vs. 62% at 12 months; p=0.42) or survival (16% vs. 56% at 12 months; p=0.46). On multivariate analyses, better survival was associated with higher Karnofsky performance score (p<0.001) and absence of extracranial metastatic disease (p=0.006).<br />Conclusion: In patients treated with SRS alone, local control of cerebral metastases from RCC was better after 20 Gy than after 16-18 Gy.<br /> (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Subjects :
- Aged
Brain Neoplasms secondary
Carcinoma, Renal Cell pathology
Female
Humans
Kaplan-Meier Estimate
Karnofsky Performance Status
Male
Middle Aged
Neoplasms, Radiation-Induced secondary
Proportional Hazards Models
Radiotherapy Dosage
Brain Neoplasms pathology
Carcinoma, Renal Cell radiotherapy
Neoplasms, Radiation-Induced pathology
Radiosurgery adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 35
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 26026128