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Low-Dose Ketamine in Chronic Critical Illness.
- Source :
-
Journal of intensive care medicine [J Intensive Care Med] 2016 Mar; Vol. 31 (3), pp. 216-20. Date of Electronic Publication: 2015 May 28. - Publication Year :
- 2016
-
Abstract
- We report a case series on the observed effects of low-dose ketamine infusions in 4 critically ill patients with varying complications related to prolonged critical illness. Doses of ketamine infusion ranged from 0.5 to 4 μg/kg/min. A low-dose ketamine infusion was used to reduce agitation in a patient requiring high doses of sedatives and analgesics. In a second patient, ketamine improved depression and anxiety symptoms. In a third patient, ketamine may have facilitated liberation from mechanical ventilation. In a fourth patient, ketamine was used for palliation to avoid lethargy. Ketamine may be considered to help decrease agitation, manage pain, facilitate opioid and benzodiazepine withdrawal, prevent respiratory depression, and potentially manage depression and anxiety in chronically critically ill patients.<br /> (© The Author(s) 2015.)
- Subjects :
- Anxiety psychology
Chronic Disease
Critical Care methods
Dose-Response Relationship, Drug
Female
Humans
Infusions, Intravenous
Male
Middle Aged
Pain psychology
Psychomotor Agitation psychology
Treatment Outcome
Analgesics administration & dosage
Anxiety drug therapy
Critical Illness psychology
Hypnotics and Sedatives administration & dosage
Ketamine administration & dosage
Pain drug therapy
Psychomotor Agitation drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1525-1489
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of intensive care medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26025196
- Full Text :
- https://doi.org/10.1177/0885066615587868