Back to Search
Start Over
Gene expression of cytokines, growth factors and apoptosis regulators in a neonatal model of pulmonary stenosis.
- Source :
-
Future cardiology [Future Cardiol] 2015 May; Vol. 11 (3), pp. 297-307. - Publication Year :
- 2015
-
Abstract
- Background: Right ventricular remodeling due to pulmonary stenosis increases morbidity in children. Its pathophysiology needs to be clarified.<br />Methods: Six newborn lambs underwent pulmonary arterial banding, seven sham operation. mRNA encoding for cytokines, growth factors and regulators of apoptosis was sequentially measured in myocardium and blood before and up to 12 weeks postoperatively.<br />Results: Experimental animals showed hypertrophy and fibrosis of the right ventricular myocardium, myocardial over-expression of CT-1-mRNA and higher blood concentrations of mRNA encoding for VEGF, TGF-β, Bak and BcL-xL than controls, respectively.<br />Conclusion: Neonatal pulmonary stenosis leads to myocardial hypertrophy that is associated with CT-1 gene expression and with activation of growth- and apoptosis pathways in blood cells.
- Subjects :
- Animals
Animals, Newborn
Cytokines biosynthesis
Disease Models, Animal
Intercellular Signaling Peptides and Proteins biosynthesis
Microscopy, Electron
Myocardium metabolism
Pulmonary Valve Stenosis metabolism
Pulmonary Valve Stenosis pathology
Real-Time Polymerase Chain Reaction
Sheep
Apoptosis genetics
Cytokines genetics
DNA genetics
Gene Expression Regulation, Developmental
Intercellular Signaling Peptides and Proteins genetics
Myocardium pathology
Pulmonary Valve Stenosis genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1744-8298
- Volume :
- 11
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Future cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 26021636
- Full Text :
- https://doi.org/10.2217/fca.15.25